Endogenous neurosteroid synthesis modulates seizure frequency
نویسندگان
چکیده
منابع مشابه
11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis.
Steroid 11β-hydroxylase (CYP11B1; EC 1.14.15.4) is a mitochondrial enzyme located in the zona fasciculata of the adrenal cortex and also in the brain that mediates the conversion of 11-deoxycortisol to cortisol and 11-deoxycorticosterone (DOC) to corticosterone. Inhibitors of CYP11B1, such as metyrapone and etomidate, reduce glucocorticoid synthesis and raise levels of DOC providing greater ava...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2010
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.21989